International Workshop
Dynein 2017

29 October – 1 November 2017
Awaji Yumebutai International Conference Center

Organization Committee of Dynein 2017
Co-sponsored by the National Institute of Information and Communications Technology (NICT)

Scope and Topics

Dynein was identified in eukaryotic cilia as the first microtubule-based force-generating ATPase a half century ago. The dynein superfamily is now known to be functionally diverse, with its members involved in a wide variety of essential cellular functions. The cell biology of axonemal and cytoplasmic dyneins has shown how defects in these motors cause a wide range of human diseases. Cytoplasmic dynein-1 transports diverse intracellular cargoes, generates forces required for cell division, and is implicated in neuro-developmental and neuro-degenerative diseases. Cytoplasmic dynein-2 is responsible for intraflagellar transport (IFT), and defects in this motor result in a ciliopathy called Bardet-Biedl syndrome. Axonemal dyneins are responsible for the movement of cilia/ flagella and dysfunction causes ciliopathies that result in infertility and improper left-right body asymmetry.

In the past five years, our understanding of the molecular basis of dynein function in both normal and disease states has advanced greatly due to structural and biophysical studies using x-ray crystallography, cryo-electron microscopy and single-molecule studies. In addition, genetic and cell biological studies have revealed novel roles and means of regulating dyneins. Thus, it is an exciting time to bring together researchers in the dynein field to discuss our most recent findings and ideas to promote further progress in the field.

Dynein 2017 is the fourth international workshop on dynein. The three previous workshops were held in 2005, 2009 and 2013 in Kobe, Japan. Dynein 2017 will focus on the molecular mechanism of axonemal and cytoplasmic dyneins, including the structure, assembly, mechanics and regulation of individual dynein molecules and dynein ensembles. The roles and regulation of dynein in cellular contexts, including how defects in the dynein machinery cause disease, will be another central focus of the workshop.

The sessions will be organized to maximize opportunities for interdisciplinary group discussion and will be complemented by poster sessions, which have been highly interactive in past meetings. Participants will be selected on the basis of their contributions to the themes of the workshop, and preference will be given to young researchers, for whom we believe this experience will particularly beneficial.

Topics

  • Structure and mechanism of dynein and dynein complexes
  • Regulation of dynein motility
  • Microtubule structure, modifications and regulation of dynamics
  • Structure and assembly of flagellar axonemes
  • Mechanism of bend formation and propagation in flagella
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